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Symbol Name ID |
Orai1
ORAI calcium release-activated calcium modulator 1 MGI:1925542 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Decreased circulating IgG level |
Decreased circulating total IgM |
Lymphopenia |
Abnormal natural killer cell count |
Recurrent aphthous stomatitis |
Stomatitis |
Hypoplasia of the thymus |
Immunodeficiency |
BCGitis |
Recurrent infections |
| Disease(s) Associated with ORAI1 | |||||||||||
| immunodeficiency 9 |
| Mouse Phenotypes | abnormal thymocyte activation |
abnormal mast cell physiology |
abnormal B cell activation |
abnormal T cell physiology |
abnormal T cell activation |
decreased susceptibility to type I hypersensitivity reaction |
abnormal cell-mediated immunity |
abnormal cytokine secretion |
decreased interferon-gamma secretion |
decreased interleukin-10 secretion |
decreased interleukin-2 secretion |
decreased interleukin-4 secretion |
blepharitis |
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| Availability | Mouse Genotype | |||||||||||||
| Orai1Gt(XL922)Byg/Orai1Gt(XL922)Byg | ||||||||||||||
| Orai1tm1Rao/Orai1tm1Rao | ||||||||||||||
| Orai1Gt(XL922)Byg/Orai1+ | ||||||||||||||
| Orai1tm1Rao/Orai1+ | ||||||||||||||
| Orai1tm1.1Hjm/Orai1tm1.1Hjm Tg(Cd4-cre)1Cwi/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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